So I get the most debilitating leg DOMS after doing squats and deads at the gym. The day after is generally ok but then the day after the day after (like today) walking, stairs and even sitting down on the toilet is hard work! 
Does anyone have any tips or tricks for prevention, remedy or cure?
Are you having anything after your workout?
I was getting the worst DOMS when i first started, then i started having a protein shake after and I have been fine the day after ever since - Still get the odd days where iām achy, but itās rare
Invest in a foam roller if you havenāt already. Oh yes, there will be tears.
Do more squats 
Iāve tried various ways to work strength sessions into my program and one thing i noticed was that when doing squats once a week iād always get DOMS. Now i do squats more frequently, say 2-3 times a week and itās fine.
Iād agree with the ādo more regularlyā bit. If I ever restart any type of lifting I get hit by DOMS, it soon goes for me as the body gets used to the movements.
Yeah I always have a protein shake afterwards.
I would love to but unfortunately I only get time to hit the gym once a week now.
If youāre used to resistance exercise and you still get DOMS itās probably nutrition. Squats/Deads deliver training stress to some of the biggest muscle groups in the bodyā¦it takes days to recover from those types of workoutsā¦if you slip into negative nitrogen balance over the course of the first few days you will develop DOMS. Maintain positive nitrogen balance. At least 1g protein/kg bodyweight. Not just right after the workout but over the course of the next three days at least.
Also, consider your goals. Do you really need to be crushing yourself with deads/squats to that extent? If youāre like me when the weight starts going on the bar itās hard to stop yourself! One trick I use with cleans/deadlifts is to do them on a thick (2") bar. That way grip limits how much weight I can put on the bar (and still clean it).
As a cyclist I find grip workouts to be a neglected resistance regime, anyhow. Heavy squats and deadlifts are probably overdone when they are done.
In that case just try to get as much as your recovery on point as possible, protein post workout, foam rolling, maybe an easy leg loosener the next day, i have used Taku in the past just to loosen up a bit and help with active recovery.
Sorry if this is bad news but lots of doms=youāre overdoing it. You gotta lift a bit easier. Your body will adapt but it might take awhile, maybe a long while, especially if you arenāt young.
Learn to love it as much as you love suffering on the bike!
I would up the protein intake day of and after. Also not sure what type of weight training you doā¦ Hypertrophy (higher rep 8+) usually makes me more sore than strength (low rep 5x5) higher weight.
Hence the D in DELAYED Onset Muscle soreness
Diet has a large impact on recovery so donāt overlook this, adequate protein for muscular repair as well as plenty of foods rich in vitamins & minerals.
Additionally the volume & intensity of your sessions, if progressive, will continue to deliver DOMās. If this stagnates then you should find that as you become conditioned to handle those loads and that volume youāll experience less. DOMās are partly a response to a new level of stimulus.
A little bit of SMR and restorative blood-flow will help speed to the recovery process too.
I dialed my weights back, just ever so slightly and included a post workout protein shake. That combined with consistent foam rolling has really helped myself, without any losses in strength.
DOMS will go away as you continue with the routine. The only way to avoid it is to build up the weight slowly and not overload, even if overload is not āheavyā.
I get a brutal set of it every fall when off-season starts and i head back into the gym. Just have to persevere for two weeks and it settles down and i can begin adding more weight. I write-off any on the bike workouts during this time as they simply cannot be done. Diet and rolling do not seem to make a difference.
Workout 2 days after the first is the key. This is when DOMS is the worst. If you canāt get to the gym, do a couple sets of 50 squats (no weight), or whatever you can handle. It sucks at the time, but youāll get rid of the DOMS much faster this way, and the first set will be the hardest.
I went to the gym last Saturday, the first time in 9 months or so, and stupidly overdid it on the legs. I already missed my both weekend workouts, Iām still walking like a 90-yr old, todayās workout (Berryessa) is looming and Iām not sure what to do. Take it easy, or will I be fine once I start the workout?
Iām thinking of maybe switching to either sweet spot or something like Baxter at high cadence, to get the blood flowing. I was planning to do a recovery workout yesterday but honestly the thought of sitting on the bike was already quite distressing. What do you guys think?
Last winter I lost a few weeks of quality training because of this. Iām usually not a cramper but with strength training I could induce cramps in following cycling workouts. I have a tendency for cramping in running, therefore eccentric contractions seem to be an issue with me. My love for trail/mountain running is really impaired by this because there is always the uncertainty if it hits me while descending. This has been issue for years, any attempt to adress is failed.
With regards to strength training Iād say one has to start really, really conservatively. I know, cyclists/triathletes have often a Type A personality but here Iād say really dial back. HOwever, I actually did, still hit me. Probably one the things where you have to try and see.
Turns out Baxter at high cadence fixed me. To the point that I did Baxter around noon and was feeling so good that I went to the gym in the evening. Itās always a good sign when legs feel better after the workout than before.
If your heavy lifting is hindering your ability to become a faster cyclist, you stop doing it.
If you just want to cycle for fun, you pick your poison and accept that DOMS is mostly likely what youāre going to have to endure to get stronger in those lifts. Leg DOMS is some of the worst ever
Like @RONDAL says above, one thing that helps a lot of people with DOMS is routine. First squats after 9 months away? Donāt expect to ride the next day. Give it a week or two of regularly going to the gym, and at some point (if you maintain generally the same weights, small increments, similar volume, etc.) it shouldnāt bother you at all.
And yes, I also have luck with some lighter spinning efforts (or short, easy runs) to get through it.