Hurt more? Maybe.
Hurt different? Yes.
It is like most other training stuff, where the more you do something, the easier it gets. If you make a large change from high cadence work to low cadence work at the same power, it changes the loading on the body.
Doing low cadence training can be very rewarding, but it’s need is dependent on each rider and their needs for whatever they train to do.
I made a compiled list about Low Cadence work for those that want to add it into their training.